Research: Cancer Host and Environment
Cancer Host and Environment is a fundamental and translational program.
Research members are focused on the interaction of cancer with host tissues—mechanistically understanding cell migration and division within the tumor microenvironment; consequences of malignancy on host systems that impact outcomes for cancer patients; parameters in the host that promote or impede cancer progression; and the response to clinical interventions.
Theme One
Impact of tumor-host interactions on cancer initiation and progression
Theme Two
Cancer interventions: harnessing host & tumor characteristics
Theme Three
Mitigating the impact of cancer and treatment on host physiology
in grant funding awarded in 2024.
Program Impact
New Study Establishes How Cells May Communicate Changes in Their Environment
Recent work from UVM Cancer Center member Alan Howe, Ph.D., highlights a newly identified pathway that connects the properties of the extracellular matrix to signals that control cell mobility/motility. Published in the Proceedings of the National Academy of Sciences, the study provides a better understanding of how cells incorporate changes in physical cues into cellular communication.
"The Vermont Model": A Blood Clot Prevention Program Improves Outcomes in Community Oncology Practices
A new study by UVM Cancer Center members Steven Ades, M.D., MSc.; Karlyn Martin, M.D.; Ryan Thomas, M.D.; and Chris Holmes, M.D., Ph.D., together with UVM Medical Center colleagues, evaluated the efficacy of “The Vermont Model,” a program that aims to prevent the onset of Venous Thromboembolism (VTE) -- common among cancer patients -- by increasing the rate of prophylactic anticoagulation in high VTE risk cancer patients. The study was published in Lancet Regional Health - Americas.
Inaugural Award will Accelerate Cancer Clinical Trials
Christopher Anker, M.D., has received the inaugural Clinician Investigator-Initiated Therapeutic Trial Opportunity (CIITTO) award from the University of Vermont Cancer Center, which supports investigators actively working to bring treatment-related, investigator-initiated clinical trials to patients of the Cancer Center. Dr. Anker’s two trials include one that provides a personalized approach for patients with high-risk factors for skin cancer; and another that addresses the treatment of brain metastases.
Danielle Brasino, Ph.D.
Assistant Professor, Department of Microbiology and Molecular Genetics
Michael Brasino, Ph.D.
Assistant Professor, Department of Electrical & Biomedical Engineering
Ashley Volaric, M.D.
Assistant Professor of Pathology
Amanda Kallen, M.D.
Reproductive Endocrinologist, Associate Professor of Obstetrics & Gynecology
